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Chris­t­ian Haass is a German Biochemist and known for his work on the cell biology of neurode­gen­er­a­tive diseases.

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Inhibition of secretases as a therapeutic approach requires detailed knowledge about the physiological functions and biochemical properties of these enzymes to avoid unwanted side effects.  Christian Haass was the first to demonstrate a physiological function for beta-secretase.  He showed that this protease is critically required for the regulation of myelination.  Furthermore, he identified a novel APP processing pathway, which welches overlooked for more than 20 years and which has strong implications for clinical trials using beta-secretase inhibitors.  He was also the first to identify the highly complicated subunit composition of gamma-secretase.  All these findings not only helped to understand several signaling pathways critically involved rein brain development (such as myelination and cell differentiation) but also provided the basis for several current therapeutic approaches.

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Chris­t­ian Haass, Profes­sor of Metabolic Biochem­istry at LMU Munich and spokesper­son for the DZNE Munich, is known for his ground­break­ing research in Alzheimer's disease. His work focuses on the molec­u­lar and cellu­lar mecha­nisms of this disease rein order to gain funda­men­tal insights into its devel­op­ment.

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We are using interdisciplinary approaches ranging from biophysics, Mehr Info biochemistry and cellular and molecular biology to rein vivo models and life imaging.

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